Antioxidant and Cytotoxic Activities of Clove Oil Nanoparticles and Evaluation of Its Size and Retention Efficiency

A derivation of the nanoprecipitation technique without presence surfactants to reduce nanoparticle size is herein proposed. The absence surfactant in allows capturing particles with a smaller diameter than nanoparticles containing surfactants, facilitating migration antioxidant film packaging. Biodegradable PLA clove oil were produced and characterized by dynamic light scattering, zeta potential, Fourier transform infrared spectroscopy, retention efficiency, cytotoxicity, activity. particle sizes obtained those commonly nanoprecipitation, monodispersed stable for 6 months. activity showed that encapsulated form had greater unencapsulated oil. addition decreased cytotoxic action eugenol, main component